// closelook @ longevity

The Finanztest for supplements.

Independent, evidence-rated longevity research. No supplement sponsorships. No pharma ads. Structured judgment from a finance analyst and a doctor.

Evidence LadderCompound ScorecardsProtocol StacksDoctor-Reviewed
// the problem
Supplement marketing is broken
ConsumerLab tests for contamination. Examine.com aggregates studies. Nobody applies the structured, independent judgment that finance professionals use for investments โ€” to the compounds they're already buying.
ConsumerLabExamine.comcloselook.health
Purity testingโœ“โ€”โ€”
Study aggregationโ€”โœ“โœ“
Evidence-level scoringโ€”Partialโœ“ Ladder
Independent A/B/C ratingsโ€”โ€”โœ“
Medical editor reviewLab teamEditorialโœ“ Doctor
Zero supplement/pharma adsโ€”โ€”โœ“
Written for finance prosโ€”โ€”โœ“
// core framework
The Evidence Ladder
Every compound on a 5-level ladder โ€” tracked as new research moves it up or down. Like a credit rating for longevity interventions.
Level 5

Human RCT Confirmed

Randomized controlled trials with clinically meaningful endpoints. Gold standard.

Level 4

Human Trial Data

Human studies with biomarker or surrogate endpoints. Promising, not definitive.

Level 3

Strong Animal + Mechanism

Robust animal data with understood molecular mechanisms. Plausible translation.

Level 2

Animal Data Only

Promising model organism results, limited mechanistic understanding.

Level 1

In Vitro / Theoretical

Cell studies, computational models, theoretical mechanisms only.

// live scorecards
Compound ratings at a glance
Updated quarterly. Each compound rated on evidence, safety, applicability, and overall assessment. Every entry doctor-reviewed.

Longevity Scorecard โ€” Q1 2026

Doctor-Reviewed
CompoundPrimary ClaimEvidenceRating
MetforminHealthspan extension, TAME trialL4A
RapamycinmTOR inhibition, immunosenescenceL3B+
NMNNAD+ precursor, cellular energyL3B
SpermidineAutophagy induction, cognitiveL4A-
TaurineMulti-system longevity, ColumbiaL2โ€“3B-
ResveratrolSirtuin activation, Sinclair thesisL2C+
// content architecture
Three research pillars
Weekend longreads for finance professionals who want health decisions with the same rigor as market research.
01

The Mechanism

Biological processes that drive aging. Deep dives into the science, translated for non-specialists.

CR ยท mTOR ยท NAD+ ยท Epigenetic clocks
02

The Molecule

Single-compound research reports. Evidence chain from animal models to human trials.

Metformin ยท Rapamycin ยท NMN ยท Taurine
03

The Condition

Chronic diseases and aging conditions. Latest research, evidence levels, off-label options.

Neurodegeneration ยท CV ยท Metabolic ยท Sleep

// editorial independence

"closelook.health never accepts sponsorships from supplement or pharmaceutical companies. Our sponsors โ€” if we choose to have any โ€” are testing services and health data platforms. Never the compounds we cover."
// revenue model
How closelook.health monetizes
Four streams, all independent of supplement sales. We sell structured judgment โ€” not products.
๐Ÿ“Š

Longevity Intelligence Tier

โ‚ฌ15โ€“25/mo for scorecards, protocol stacks, quarterly Evidence Ladder updates, Ask-the-Doctor Q&A

primary revenue
๐Ÿ”—

Health Tech Affiliates

Oura, InsideTracker, glucose monitors. Testing & monitoring only. Never supplement brands.

same model as .money
๐Ÿข

Curated Sponsors

Testing services and health data platforms only. Published policy: no supplements, no pharma.

premium, selective
๐Ÿ“ˆ

Longevity Index

ABR-style scoring for interventions. Systematic rating framework. Needs 20+ posts foundation.

long-term product
// editorial team
Finance analyst + doctor
The combination that makes this work. Finance brings structured judgment. Medicine brings clinical accuracy.
Research & Analysis

Thomas

Managing Director, Closelook Venture GmbH. Quantitative frameworks applied to longevity science.

Medical Editor

Dr. [Name]

Specialist in anti-aging and preventive medicine. Reviews every scorecard and protocol stack.

// ecosystem
Publishing โ†’ Engine โ†’ Commerce
publishing
Substack
โ†’
engine
closelook.net
โ†’
commerce
closelook.health